CFTR and cystic fibrosis: Notably,in the humanized mouse model expressing the R98H-α-sarcoglycan,recovery of the defective protein corresponded to improvement in musclestrength.12−14 Thus, the 4′-methyl-4,5′-bithiazolederivatives, first screened for the treatment of cystic fibrosis,seemed to hold a promiscuous action, being able to recover proteins,different in terms of structure, but sharing with CFTR a similar fatewhen carrying missense mutations.