In this context, more recent studies aimed at investigating theefficacy of constrained bithiazoles that showed higher maximum efficacyin cystic fibrosis cells, however without significant enhancementof potency.8,15 Additionally, Martina et al.very recently reported a SAR study based on bithiazole derivativesinspired by CFTR correctors aiming at the identification of multifunctionalantibacterial agents.16 This evidence concerns the gene CFTR and cystic fibrosis.