500 non-obese individuals and 858 centrally obese patients were chosen at random for this study. Serum-free triiodothyronine (FT3), free thyroxine (FT4), thyroid-stimulating hormone (TSH), BMI, WHR, FBS and insulin HOMA-IR, lipid concentrations, and blood pressure were all determined for every single participant. The Centre for Epidemiological Studies-Depression (CES-D) scale was used to measure depression. The gene discussed is INS; the disease is major depressive disorder.