Briefly, endothelial cell dysfunction, increased coagulation activity during disease exacerbation, excessive platelet activation, evidence of oxidative stress, perivascular fibrin(ogen) deposition, higher plasma levels of prothrombin and factor X (FX), complement activation, vascular occlusion within demyelinating lesions, altered blood-brain barrier (BBB) permeability, and hypoxia-like tissue injury have all been reported in people with multiple sclerosis (6, 7). Here, F10 is linked to multiple sclerosis.