The age, gender, hepatitis B virus (HBV) infection, previous surgery, previous TACE, tumor distribution, tumor size, vascular invasion, extrahepatic metastasis, Child-Pugh grade, albumin-bilirubin (ALBI) score, ECOG PS score, alpha-fetoprotein (AFP), and Protein Induced by Vitamin K Absence or Antagonist II (PIVKA-II) were analyzed and showed no significant differences between the two groups (p > 0.05). The gene discussed is AFP; the disease is neoplasm.