The SPIOMET group had reduced hirsutism (WMD [95% CI]: −3.00 [−5.77, −0.23], p = 0.03), SHBG (−29.00 nmol/l [−39.56, −18.44], p < 0.0001), fasting insulin (−62.00 pmol/l [−81.40, −42.60], p < 0.0001), ALT (−0.09 μkat/l [−0.16, −0.02], HOMA-IR (−1.80 [−2.42, −1.18], p < 0.0001), LDL (−0.05 mmol/l [−0.78, −0.22] p = 0.0004), CRP (−18.10 mmol/l [−25.75, −10.45], p < 0.0001), and FAI (−2.20 [−4.38, −0.02], p = 0.05), but higher androstenedione (1.00 nmol/l [0.29, 1.71], p = 0.006) compared with the COCP group. The gene discussed is CRP; the disease is Hirsutism.