,31 In meta-analysis, daily anti-androgen use was superior for reducing hirsutism (WMD [95% CI]: −3.48 FG score [−4.58, −2.39], p < 0.0001) and androstenedione (−0.30 ng/ml [−0.50, −0.10], p = 0.004), with no differences in SHBG, testosterone, or DHEAS (n = 80; Table S3). This evidence concerns the gene SHBG and Hirsutism.