In meta-analysis, anti-androgens + lifestyle resulted in lower hirsutism (n = 265, WMD [95% CI]: −1.59 [−3.06, −0.12], p = 0.03), fasting insulin (n = 213; −2.11 μU/ml [−3.97, −0.26], p = 0.03) and fasting glucose-insulin ratio (n = 176; −1.12 [−1.44, −0.79], p < 0.0001), and higher HDL (n = 37; 0.21 mmol/l [0.05, 0.37], p = 0.01), frequency of menstruation (n = 176, 0.79 cycles/year, [0.05, 1.53], p = 0.04) and SHBG (n = 89; 7.70 nmol/l [0.75, 14.66], p = 0.03), compared with metformin + lifestyle (Table S4). The gene discussed is SHBG; the disease is Hirsutism.