The relationship between insulin resistance and elevated blood pressure can be discussed from the following perspectives: 1 (11–13, 52, 53) The prevailing view in most theoretical studies is that compensatory hypersecretion of insulin by pancreatic Beta-cells in the early stages of diabetes can result in hyperinsulinemia, which can hyper excite sympathetic nerves. The gene discussed is INS; the disease is hyperinsulinism.