Notably, several genes were found associated with the platelets activation, signaling, degranulation, and aggregation, and included ACTN1, ANXA5, AVPR1A, CALU, CAP1, CD63, CDC37L1, DGKD, F2R, FAM3C, FCER1G, FN1, GNG12, HSPA5, MANF, PDPN, PFN1, PPIA, PTPN1, RAP1B, SERPINE1, THBS1, TUBA4A, and YWHAZ. Among these, five genes CAP1, DGKD, F2R, FAM3C, and GNG12 have been prioritized for the first time in HF (Supplementary Figure S4). The gene discussed is PFN1; the disease is hydrops fetalis.