In addition to the afore-mentioned etiologies of HF, several studies have shown in the recent past that dysregulation of the epitranscriptomic modifiers such as mRNA N6-methyladenosine (m6A) writers (METTL3, and METTL14), readers (YTHDF1, YTHDF2, and YTHDF3), and erasers (FTO, ALKBH5), which affect the stability, splicing, translation efficiency, and degradation of the mRNA (14–18), have plausible roles in the pathophysiology of HF (19). Here, YTHDF3 is linked to hydrops fetalis.