ADK overexpression as a general response to astroglial activation (Boison and Aronica, 2015) is considered a neuropathological feature of temporal lobe epilepsy (Aronica et al., 2011), focal cortical dysplasia (Guo et al., 2023), and contribute to the epileptogenic process itself (Gouder et al., 2004). The gene discussed is ADK; the disease is temporal lobe epilepsy.