The mAb31-8D3scFv BSA retains high affinity binding to Aβ oligomers, and the engagement by the mAb31-8D3scFv BSA of Abeta protofibrils in the brain of the ArcSwe AD transgenic mouse was demonstrated following the IV administration of 5 mg/kg of this BBB-penetrating BSA (Rofo et al, 2022). This evidence concerns the gene APP and Alzheimer disease.