Furthermore, in the case of Venlafaxine treatment in the GSE32280 dataset, the NRG1 was down-regulated in HCs compared to MDD patients before and after the treatment (FC = −0.44, p = 0.04) and (FC = −1.44, p = 0.001), respectively, while it was up-regulated when comparing MDD patients before and after Venlafaxine treatment (FC = 1.5, p = 0.001). Here, NRG1 is linked to major depressive disorder.