Likewise, in the GSE76826 dataset, the NRG1 was down-regulated once comparing HCs to MDD patients before remission and after remission (FC = −0.87, p = 0.0007) and (FC = −0.85, p = 0.0005), respectively, while, no gene expression changes were detected once comparing MDD patients before and after remission. Here, NRG1 is linked to major depressive disorder.