The immune deficiency (IMD), Janus kinase/signal transducer and activator of transcription (JAK/STAT), and Toll pathways are crucial for the control of bacterial (e.g., B. burgdoferi, Anaplasma marginale, and A. phagocytophilum infections), viral, and parasitic challenges (Smith et al., 2016; McClure Carroll et al., 2019; Fogaça et al., 2021). The gene discussed is TLR4; the disease is Immunodeficiency.