To explore the causal relationship between five circulating lipid traits (apo A1, apo B, HDL-C, LDL-C, and TG) and the risk of periodontitis, this study conducted a two-sample univariable and multivariable MR study using data from the UK Biobank (UKB) (RRID: SCR_012815) and GeneLifestyle Interactions in Dental Endpoints (GLIDE) consortium. This evidence concerns the gene APOB and periodontitis.