TNF and periodontitis: This seems to be because, during periodontitis, inflammatory factors [C-reactive protein (CRP), tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and IL-6] released into serum can promote adipose tissue lipolysis and inhibit lipoprotein lipase activity, increase the synthesis of TG, and reduce the clearance of TG and LDL-C (45).