BMI1 and familial pancreatic carcinoma: MiR-181a has been shown to promote the development of pancreatic cancer by suppressing the tumor suppressor genes PTEN and MAP2K4 (30), whereas downregulated miR-155, miR-135a, miR-7, miR-29b, and miR-101 aid in apoptosis evasion by the targeting of X-linked inhibitor of apoptosis (XIAP) (31), Bmi1 (32), MAP3K9 (33), DNMT3b (3), and RLIP76 (34), respectively.