TGFBR2 and neoplasm: Hypoxic MCF7 exhibited the downregulation of many anti-angiogenic miRNAs at cycle 10, including miR-15a/16 which targets VEGF-A (74), miR-17 which targets several tumor angiogenesis-inducing genes, including TGFBR2, HIF1, and VEGFA (75), miR-93 which targets WNK lysine deficient protein kinase 1 (WNK1) (76), and miR-20a which targets VEGF (77).