NUSAP1 expression in SCLC was significantly higher than that in LUAD, and the average level of SCLC sample data was higher than that of large cell lung cancer and squamous cell lung cancer; the average expression level of TTK in SCLC was higher than that of normal, large cell lung cancer, LUAD and squamous cell lung cancer. The gene discussed is NUSAP1; the disease is lung large cell carcinoma.