In LUAD and SCLC tissues, missense mutations, truncating mutations, and splicing mutations occupy the top three TP53 mutations, respectively, (Figures 3D,E), and TP53R273C/L/H mutations are the most common mutation types of TP53 in LUAD and SCLC tissues (Figures 3F,G). The gene discussed is TP53; the disease is small cell lung carcinoma.