LGALS1 and inflammatory bowel disease: Notably, upregulation of ST6GAL1 mRNA, in colonic biopsies from IBD patients, was correlated with interruption of galectin-1 signaling, whereas higher C2GNT1 mRNA levels were positively correlated with galectin-1 binding and suppression of intestinal inflammation, highlighting an alternative mechanism through which glycosylation shapes gut immunity [25].