LGALS1 and Sepsis: To illustrate this concept, galectin-1 has been shown to function as a danger-associated molecular partner (DAMP) or alarmin that amplifies the inflammatory response during sepsis [53]. Moreover, galectin-3 has shown broad pro-inflammatory activities by modulating survival, differentiation, recruitment and effector functions of neutrophils, mast cells, macrophages and T cells [54, 55].