PINK1 and amyotrophic lateral sclerosis: PINK1-Parkin double knockout results in the accretion of damaged mitochondria, which lowers mitochondria function and causes degeneration of ALS neuromuscular junctions.214 Conversely, Palomo et al. reported that in the SOD1-G93A mouse model, ablation of the Parkin gene reduces mitochondria depletion and delays ALS progression.178 However, to date, there has been no plausible explanation for these discrepancies.