Depletion of FIS1 attenuates mitophagy, resulting in a severe loss of their ability to self-renew and promotion of myeloid differentiation in Leukemia stem cells.300 In addition, the expression of FIS1 also promotes stemness in the lung cancer stem cells of human via mitophagy.301 It may offer hope for a cure for cancer if the role of mitophagy in cancer stem cells can be applied therapeutically. Here, FIS1 is linked to cancer.