In addition, Bhandari et al. found that lack of Parkin in Drosophila causes mitochondria dysmorphology and depolarization in cardiomyocytes, resulting in dilated cardiomyopathy.221 Unlike mice, Parkin redundant genes are deficient in Drosophila, which more underscores the importance of PINK1-Parkin-mediated mitophagy for removing damaged mitochondria in cardiomyocytes. This evidence concerns the gene PRKN and dilated cardiomyopathy.