RIPK1 and heart failure: Further studies found that the mitophagy pathway activated after transthoracic aortic constriction is primarily ULK-, Rab9-, Drp1-, and receptor interacting protein 1 (Rip1)-dependent alternative mitophagy, instead of Parkin-, LC3-, ATG7-dependent mitophagy.225 TAT-Beclin1 treatment reactivates traditional or alternative mitophagy to defer the development of heart failure.225