HSPA5 and neoplasm: Given the facts that transcription factor Yin Yang 1 (YY1) can selectively regulate GRP78 transcription by occupying the Grp78 promoter under ERS conditions [51], that PARylation of YY1 has been observed under DNA damage in tumor cells [52], and that YY1 has been implicated in an important role in oocyte maturation and GC expansion [53], we therefore asked whether PARP1 may target YY1 for PARylation, which then affects Grp78 promoter occupation and Grp78 transcription in GCs during primordial follicle activation.