Whereas depletion of either CD8+ or CD4+ T cells alone did not affect treatment efficacy of olaparib and AZD1775 suggesting that the cytotoxicity of both CD8+ and CD4+ T cells is essential for the anti-tumour efficacy of combined PARP and WEE1 inhibition in the BRCA1/2 wild-type AT3OVA TNBC model. This evidence concerns the gene BRCA1 and neoplasm.