These primary conditional mouse cell lines carry mutations seen in both adult and pediatric high-grade gliomas (namely, (1) BrafV600E, INK4ab/Arf−/−, PTEN−/−, for PS5A1 GEMM, and (2) BrafV600E, P53−/−, PTEN−/−, for 73 C GEMM). Here, TP53 is linked to central nervous system cancer.