To generate a mouse glioma, it typically requires the activation of an oncogene (e.g., EGFR mutation, PDGFRa, cMET, BrafV600E) in combination with loss of one or more suppressors (PTENf/f, P53f/f, and INK4a/b−/−Arf f/f). The gene discussed is EGFR; the disease is glioma.