MAP2K7 and glioblastoma: In addition, one of the major advantages of our combination of mutations is that while there is significant diversity of oncogenes that are seen in GBM which has influenced the choice of mutations that are selected to generate GEM models48–51, they share one common important feature that they all to some extent activate a common downstream RAS/RAF/MEK/ERK signaling pathway, which in turn regulates transcriptional networks to drive tumorigenesis.