These GEMMs were generated using neural-stem-cell–derived PS5A1 (BrafV600E, INK4ab/Arf−/−, PTEN−/−, Supplementary Fig. 2a, c) and astrocyte-derived glioma cell line 73 C (BrafV600E, PTEN−/−, P53−/−, Supplementary Fig. 2b, c)29,30. The gene discussed is CDKN2A; the disease is central nervous system cancer.