To evaluate liposome delivery of gene editing complex targeting the OHCs, we selected a dominant deafness mouse model (Atp2b2Obl/+ mouse), which carries a mutation Oblivion (Obl) in the second isoform of the plasma membrane Ca2+-ATPase (Atp2b2) gene that impairs the calcium pumping ability of the PMCA2 protein18. This evidence concerns the gene ATP2B2 and deafness.