For NSCLC, the TERT polymorphism (C vs. A) was associated with the risk of NSCLC in both smoking group and non-smoking group (Smoking: [OR] = 1.20, 95%CI [1.05, 1.36]; Non-smoking: [OR] = 1.33, 95%CI [1.18, 1.50]), and the non-smoking group had a higher risk of NSCLC than the smoking group (C vs. A: Smoking: [OR] = 1.20/Non-smoking: [OR] = 1.33), and it’s also found that non-smokers had the highest risk of NSCLC in Asians ( [OR] = 1.35, 95%CI [1.17, 1.55]) (Fig. S4 in supplemental content, Table 7). The gene discussed is TERT; the disease is non-small cell lung carcinoma.