To figure out the role of CDK7-YAP-LDHD axis in the regulation of ferroptosis induced by D-lactate further, we added various concentrations of ferroptosis inducer Erastin to CDK7/YAP/LDHD-overexpressed and their control ESCC cells, then measured the sensitivity of these cells treated with Erastin for 24 h. The gene discussed is CDK7; the disease is esophageal squamous cell carcinoma.