LDHD and neoplasm: To evaluate the impact of LDHD on tumor-forming capacity in vivo, we transplanted subcutaneously 1000 and 100 LDHD-overexpressed and control KYSE150 cells per site into NOD/SCID mice, then we found that increasing LDHD greatly contributed to a stronger tumorigenic potential than control group as reflected by increased frequency of tumorigenic cells (Fig. 6d, e).