We did not observe significant improved function of CD8 + T cells after cultured with the supernatant from cisplatin resistant BCa cells with silencing MAT2A or circARHGAP10 over-expression (Fig. S9E), which indicated MAT2A was not in charge of the consumption of methionine in cisplatin resistant BCa cell from tumor microenvironment. This evidence concerns the gene MAT2A and neoplasm.