PTGR1 and breast cancer: PTGR1 belongs to the medium-chain dehydrogenase/reductase superfamily and plays a vital role in regulating the arachidonic acid metabolism pathway.35 Accumulating evidence indicates that PTGR1 is overexpressed in many cancer types, including lung cancer, breast cancer, gastric cancer, pancreatic cancer and liver cancer, and is associated with poor prognosis.35 Our bioinformatics analysis revealed that PCa patients with high PTGR1 expression had shorter biochemical recurrence (BCR)-free survival times than those with low PTGR1 expression.