Our experiments for the first time showed that: (1) this SE increased PTGR1 expression in DU145-MetR cells when bound by SRF and RUNX3, and (2) elevated expression of PTGR1 accelerated cell cycle progression by promoting the progression from the G0/G1 to the S and G2/M phases, reducing the inhibitory effect of metformin on PCa. This evidence concerns the gene RUNX3 and posterior cortical atrophy.