Tumoral infiltration of other immune subsets including CD4+ T cells, monocytes (CD11b+Ly6ChighLy6G−), granulocytes (CD11b+Ly6GhighLy6Clow), tumor-associated macrophages (TAMs, CD11b+F4/80highLy6ClowLy6G−), dendritic cells (DCs, CD11c+MHC-II+) and regulatory T cells (Treg, CD4+CD25+FOXP3+) was also not changed by 5-NL treatment (Fig. 2B and Supplementary Fig. 2A and B). The gene discussed is ITGAM; the disease is neoplasm.