In liver cancer, circRHBDD1 can recruit YTHDF1 and combine with m6A modified PIK3R1 mRNA, improve the translation level of PIK3R1 mRNA, promote the glycolysis of liver cancer cells through subsequent PI3K/AKT signal transduction pathway and make liver cancer resistant to anti-PD-1 treatment. The gene discussed is PIK3R1; the disease is liver cancer.