Functional studies show that HLA complex P5 (HCP5) can enhance the binding of YTHDF1 and m6A-modified HK2 mRNA, thus improving the stability of HK2 mRNA, promoting the aerobic glycolysis of ESCC cells, and increasing the malignant phenotype of ESCC [127]. This evidence concerns the gene HCP5 and esophageal squamous cell carcinoma.