In colorectal cancer, METTL3 can induce HIF-1α mRNA methylation and recruit IGF3BP3 to improve its stability, resulting in an increase in the transcription level of LDHA; On the other hand, METTL3 catalyzes m6A modification in the CDS region of LDHA mRNA and recruits YTHDF1 to bind with m6A-LDHA mRNA. Here, METTL3 is linked to colorectal cancer.