In our evaluation of tumour-infiltrating lymphocytes (TILs) and Foxp3 expression in tumour tissues using immunohistochemistry (IHC) in 358 patients, patients with high levels of CD4 + T cells or CD8 + T cells exhibited better prognosis (Fig. 4C, E, all p < 0.05). This evidence concerns the gene CD4 and neoplasm.