After adjustment with other prognostic confounders including age, sex, smoking status, drinking status, tumor location, histology, N stage, tumor stage, CEA level, NSE level, and Cyfra21-1 level, the associations remained significant (aHR, 0.09; 95%CI, 0.01–0.61 for TLMR and cHR, 0.12; 95%CI, 0.03–0.73 for SUVmax) (Table 4). The gene discussed is ENO2; the disease is neoplasm.