Interestingly, the 1318 targets characteristic only for HCT116 included transcripts playing a role in DNA-damage response and apoptotic pathway regulation (e.g., CDK4, BAX, CASP2, BCL3, BCL10), proteasome-mediated degradation (e.g., USP7, CUL3, TRIM2, PSMA6, PSMA5, PSMD8), and autophagy (e.g., LAMTOR1, GABARAPL2) and included numerous components of transcription initiation mediated by DNA polymerases I and II (e.g., POLR1A, POLR1B, POLR1C, POLR2D, MED4, MED14, MED20, MED24, TAF4, TAF9) (Fig. 6B,C) suggesting that IGF2BP3 might be involved in the regulation of these processes in colon cancer. The gene discussed is PSMD8; the disease is malignant colon neoplasm.