CUL3 and colonic neoplasm: Interestingly, the 1318 targets characteristic only for HCT116 included transcripts playing a role in DNA-damage response and apoptotic pathway regulation (e.g., CDK4, BAX, CASP2, BCL3, BCL10), proteasome-mediated degradation (e.g., USP7, CUL3, TRIM2, PSMA6, PSMA5, PSMD8), and autophagy (e.g., LAMTOR1, GABARAPL2) and included numerous components of transcription initiation mediated by DNA polymerases I and II (e.g., POLR1A, POLR1B, POLR1C, POLR2D, MED4, MED14, MED20, MED24, TAF4, TAF9) (Fig. 6B,C) suggesting that IGF2BP3 might be involved in the regulation of these processes in colon cancer.