Furthermore, in the experimental SSc model of KLF5+/−;Fli1+/− mice, isolated dermal endothelial cells displayed a reduced expression of the endothelial markers vascular endothelial-cadherin and CD31, suggesting that KLF5 transcription factor deficiency may participate in the induction of EndMT in SSc [49]. The gene discussed is PECAM1; the disease is systemic sclerosis.