For example, hyperactivity of PTPN22 in vitro might lead to produce reactive oxygen species, driving RA through abnormal inflammatory response and joint damage.29PTPN22 has also been suggested as a preclinical molecular signature for RA.30 Existing evidence has proved that a part of novel RA genes exhibits immune-related features. The gene discussed is PTPN22; the disease is rheumatoid arthritis.