Consistent with our observations that Dnase1l3-KO mice had significantly more damaged cells in the colon than WT mice after AOM dosing (Figure 2, C and D), Dnase1l3-KO mice recovered more slowly than WT mice after the first cycle of DSS treatment, as indicated by greater body weight loss (Figure 3A) and higher incidence of bleeding and diarrhea (Figure 3B and Supplemental Figure 3B). The gene discussed is DNASE1L3; the disease is infectious otitis media.