In support of the notion that the enhanced tumor growth in Dnase1l3-deficient mice might be a result of impaired DC-mediated activation of cytotoxic T cells, scRNA-Seq analysis of the CD45+ cells in MC38 tumors (Supplemental Figure 9A) revealed that tumors from KO mice were enriched with dysregulated cytotoxic T cells compared with those from WT mice (Supplemental Figure 9B and Supplemental Table 4). Here, DNASE1L3 is linked to neoplasm.