To directly investigate the possible involvement of DNASE1L3 in suppressing tumorigenesis, we employed a well-established chemically induced CRC model, AOM/dextran sulfate sodium (AOM/DSS) model (20, 21) in Dnase1l3 WT and Dnase1l3-KO mice (Figure 3A, top). This evidence concerns the gene DNASE1L3 and colorectal carcinoma.