This analysis confirmed that DNASE1L3 has the highest expression in cDC1 and cDC2 among myeloid cells in normal human colonic tissues (Supplemental Figure 1C) and further revealed that its expression in both cDC subtypes, particularly cDC2, was significantly downregulated in human CRC tumors compared with adjacent normal tissues (Figure 1C and Supplemental Figure 1C). The gene discussed is MPPE1; the disease is colorectal carcinoma.