The expression of markers of monocytes/macrophages were induced in tumors in both WT and Dnase1l3-deficient mice in the AOM/DSS CRC model (Figure 4C), but proinflammatory cytokines produced by those cells were not sufficient to suppress tumor progression in Dnase1l3-KO mice (Figure 3). Here, DNASE1L3 is linked to infectious otitis media.