DNASE1L3 and autoimmune disease: Specifically, cluster 3 cDC2 isolated from MC38 tumors in Dnase1l3-KO mice had decreased GSVA scores in gene sets associated with proteasome, graft-host interaction, autoimmune diseases, and antigen processing and presentation, compared with those from WT mice (Supplemental Figure 7F; cDC2, cDC3).