In the present study, we identified the reduced expression of DNASE1L3 as a potential biomarker for poor prognosis and reduced tumor immune infiltration in multiple human cancers through bioinformatics analyses of TCGA data sets (Figure 1 and Supplemental Figure 1), and this observation was recently confirmed by another bioinformatics study performed in CRC (33). Here, DNASE1L3 is linked to neoplasm.