The expression of markers of monocytes/macrophages were induced in tumors in both WT and Dnase1l3-deficient mice in the AOM/DSS CRC model (Figure 4C), but proinflammatory cytokines produced by those cells were not sufficient to suppress tumor progression in Dnase1l3-KO mice (Figure 3). The gene discussed is DNASE1L3; the disease is colorectal carcinoma.