Consistent with these observations, expression of the macrophage and DC markers Adgre1 (F4/80), Nos2 (Inos), Arg2 (Arginase-2), and Itgax (Cd11c), and various inflammatory cytokines was significantly higher in the colon of Dnase1l3-KO mice than those of WT mice, mostly around the first cycle of AOM/DSS treatment (D19) (Figure 4C). This evidence concerns the gene ITGAX and infectious otitis media.