Specifically, cluster 3 cDC2 isolated from MC38 tumors in Dnase1l3-KO mice had decreased GSVA scores in gene sets associated with proteasome, graft-host interaction, autoimmune diseases, and antigen processing and presentation, compared with those from WT mice (Supplemental Figure 7F; cDC2, cDC3). The gene discussed is SEPTIN7; the disease is autoimmune disease.