To better understand the mechanisms underlying Dnase1l3 deficiency–induced tumorigenesis, we carried out genome-wide transcriptomic analysis of the whole colon tissue from Dnase1l3 WT and Dnase1l3-KO mice before AOM/DSS treatment (D0), after treatment with 1 cycle of AOM/DSS plus 5-day recovery (D19), and 24 days after treatment with 3 cycles of AOM/DSS (D80) (for the experimental timeline, see Figure 3A). Here, DNASE1L3 is linked to infectious otitis media.