To test whether the observed downregulation of DNASE1L3 in human tumors is due to a reduced number of DNASE1L3-expressing cells or due to its intrinsic downregulation in those cells, we analyzed a recent public single-cell gene expression profiling study of the CD45+ myeloid population in human colorectal tumors (18). The gene discussed is DNASE1L3; the disease is colorectal neoplasm.