CD8A and neoplasm: In particular, the mRNA levels of Lyz2 and S100a9, 2 top downregulated genes in CD8+ T cells from syngenic MC38 tumor in KO mice (Figure 6A and Supplemental Table 6), were dramatically induced in OT-I CD8+ T cells cocultured with WT DCs loaded with the apoptotic MC38-OVA (Figure 6H).