DNASE1L3 and neoplasm: Given that Dnase1l3 is highly expressed in cDCs (6, 7, 18), these observations further suggest that the transition from the early phase of proinflammatory effect to the late phase of immune-suppressive antitumor state in Dnase1l3-KO mice may be mediated by immune cells, particularly cDCs, in the tumor microenvironment.