At the recovery phase following the first DSS treatment (D19), Dnase1l3-KO mice also had reduced colon length (Supplemental Figure 3C) and impaired recovery of tissue damage (Supplemental Figure 3D), and they showed splenomegaly, as previously reported (6) (Supplemental Figure 3E). The gene discussed is DNASE1L3; the disease is Splenomegaly.