LEPR and Insulin resistance: Although ReVgatKOGlp1r mice exhibited elevated insulin concentrations and impaired glucose tolerance like that of KO mice, their ad libitum–fed blood glucose concentrations were close to normal (Figure 5, F–H, and Supplemental Figure 13), consistent with preserved control of baseline glucose by non-LepRbGlp1r GABAergic Lepr cells, despite the obesity-mediated insulin resistance and glucose intolerance of ReVgatKOGlp1r mice.