PBX1 and neoplasm: To determine whether SETD1A regulates SEs, we annotated 583 SEs and 749 SEs in CD24+CD133+ liver CSCs and SETD1A-knockdown CD24+CD133+ liver CSCs, respectively, and observed that SE-associated genes, such as FNDC3B, PTP4A1, PBX1 (35), and ELF3 (28), promote CSCs’ self-renewal and tumor progression in CD24+CD133+ liver CSCs (Figure 4D).