GO analysis showed that co-occupied targets of SETD1A and PABPC1 as well as PABPC1, SETD1A, and H3K4me3 were enriched for protein phosphorylation, gene transcription, apoptosis, cell cycle, cell migration, and TGF-β signaling, indicating that SETD1A interacted with PABPC1, an interaction that is essential for the transcriptional activation of SETD1A-regulated oncogenes, to activate the co-regulated targets of SETD1A to promote HCC stemness and progression (Figure 5, M and N). This evidence concerns the gene TGFB1 and hepatocellular carcinoma.