IRAK1 and hepatocellular carcinoma: CUT&Tag assay showed that SETD1A and H3K4me3 co-occupied the promoters of some known drivers of HCC stemness, such as PRMT6, BMI1, SOX9, ZIC2, ANGPTL4, PDK4, and IRAK1 (24), suggesting SETD1A activated the transcription of these genes.