Here, we confirmed our earlier findings that Nlrp12–/– mice develop more severe colitis with AOM/DSS treatment (Supplemental Figure 3, A–D), which is accompanied by increased activation of NF-κB and ERK, and higher expression of inflammatory cytokines, including Il6, Il1b, Cxcl1, and Cxcl2, at the early time points of colorectal tumorigenesis (Supplemental Figure 3, E–G). Here, IL1B is linked to colitis.