IL6 and colitis: Here, we confirmed our earlier findings that Nlrp12–/– mice develop more severe colitis with AOM/DSS treatment (Supplemental Figure 3, A–D), which is accompanied by increased activation of NF-κB and ERK, and higher expression of inflammatory cytokines, including Il6, Il1b, Cxcl1, and Cxcl2, at the early time points of colorectal tumorigenesis (Supplemental Figure 3, E–G).