To verify the epithelial cell–specific role of NLRP12 in the regulation of CRC, we generated epithelial cell–specific Nlrp12-knockout (Nlrp12-KO) mice by crossing Nlrp12fl/fl mice (Supplemental Figure 6, A and B) with Vil-Cre mice (Supplemental Figure 6C). This evidence concerns the gene VIL1 and colorectal carcinoma.