Notably, the activation of NF-κB and ERK pathways as well as induction of proinflammatory cytokines, including Il1b, Il6, and Tnfa were comparable in tumors of Nlrp12–conditional KO mice and their WT counterparts (Figure 5, E and F, and Supplemental Figure 6D), further emphasizing epithelial cell–specific regulation of the Wnt/β-catenin pathway in NLRP12-mediated protection against CRC. The gene discussed is TNF; the disease is colorectal carcinoma.