LGR5 and neoplasm: Furthermore, the expression of EMT genes and oncogenes, including Mmp3, Mmp7, Mmp8, Fn1, Vim, Foxc2, Ctnnb1, Lgr5, Axin2, cMyc, Ccnd1, and Yap1, was significantly high in the tumor of cohoused Nlrp12–/– compared with WT mice (Figure 2I).