Data from animal and human models of non-infectious acute lung injury and acute respiratory distress syndrome indicate that ErbB1 and ErbB2 are key regulators of inflammation and tissue injury via activation of the p38 MAPK, AKT/mTOR, and Ras/RAF/MEK/ERK pathways (20, 30–33). This evidence concerns the gene AKT1 and acute respiratory distress syndrome.