Consistent with our RUNX1-KO HSPC model, RUNX1mut AML cells expressed higher levels of IL3RA transcripts compared with RUNX1-WT (RUNX1wt) AML cells, with no difference in CSF2RA or CSF3R expression (Figure 5, E–G). The gene discussed is IL3RA; the disease is acute myeloid leukemia.