For example, a diagnosis of IDH-wildtype grade 4 diffuse glioma (glioblastoma) includes 3 new molecular genetic criteria: concurrent gain of the whole chromosome 7 and loss of the whole chromosome 10 (+7/−10), telomerase reverse transcriptase (TERT) promoter mutation, and epidermal growth factor receptor (EGFR) amplification. The gene discussed is EGFR; the disease is glioblastoma.