NFKB1 and pulmonary fibrosis: These actions could be attributed to the MTX’s ability to activate the leukocytes to increase the liberation of cytokines, which have a fundamental role in lung fibrosis formation through the epithelial-mesenchymal transition process and stimulation of NF-kβ and activator platelet-1 through ROS generation (Al Kury et al. 2020).