Middle panel: Lenalidomide induces ubiquitin‐dependent degradation of IKZF1/IKZF3; however, residual members of the MM‐specific activator complex, c‐FOS/c‐JUN, bind to the activator protein‐1 (AP‐1) consensus sequences, which are present in the vicinity of the IKZF‐binding sites of some genes including IRF4 and SLAMF7, leading to sustained expression of these genes and lenalidomide resistance. Here, IKZF3 is linked to Miyoshi myopathy.