Left panel: In multiple myeloma (MM), IKZF1/3 binds to the canonical IKZF‐binding motif CTTCC in a complex with c‐FOS/c‐JUN to activate the transcription of genes involved in the growth and survival of MM cells such as interferon regulatory factor 4 (IRF4) and SLAMF7. This evidence concerns the gene FOS and plasma cell myeloma.