For example, c‐FOS is known to be positively regulated by the histone H3K36 methyltransferase MMSET/NSD2, which is ectopically expressed due to the chromosome translocation t(4;14) and might contribute to the overexpression of IRF4 and SLAMF7 as a direct transactivator in high‐risk MM with t(4;14).49, 50. Here, NSD2 is linked to Miyoshi myopathy.