LKB1 mutations are associated with an immune-excluded TME (44) and loss of LKB1 in KRAS-mutant mouse models drives immune evasion by promoting infiltration of neutrophils via IL6 (45) and suppressing tumor-intrinsic STING signaling (46), type I IFN signaling, and antigen presentation (47). The gene discussed is STK11; the disease is neoplasm.