A KEGG pathway analysis indicated that insulin signaling, MAPKsignaling, AMPK signaling pathway, and autophagic pathway were enrichedby total upregulated genes, whereas Rap1, cAMP, and AGE-RAGE signalingpathways were enriched by total downregulated genes, indicating PCOS-specificpathways in the ovary of the BPA lineage. The gene discussed is INS; the disease is polycystic ovary syndrome.