SHBG and hyperandrogenism: ThePCOS biomarker SHBG protein is a circulating homodimeric glycoproteinsynthesized by hepatocytes with a stronger affinity for testosteronethan estrogen.164 The expression of shbg was decreased in the liver of the BPA lineage females.Such a decrease in expression has been found to positively correlatewith the bioavailability of free testosterone,165 hyperandrogenism,166 fatty liverdisease, hyperinsulinemia, and PCOS.