Downregulation of apoB isoforms may result in low levels of TGs and cholesterol in thecirculation as well as an extensive accumulation of lipid dropletsin hepatocytes, indicating the development of NAFLD phenotype.163 In BPA lineage females, the levels of shbg mRNAs were significantly decreased in the liver, suggestinganother possible link between transgenerational PCOS and NAFLD. This evidence concerns the gene APOB and metabolic dysfunction-associated steatotic liver disease.