Previous studies showed that upregulation ofKDM2B and HDAC and dysregulation of EHMT1/2 are linked to DNA damageand dysregulation of the cell cycle, and overexpression of HDAC is linked to ovarian cancer.134,135 Together with the published literature, differential expressionof PCOS-specific genes and epigenetic genes linked to histone modificationsand DNA methylation indicates a role of epigenetic genes associatedwith PCOS phenotype in the ovary of BPA lineage fish. The gene discussed is EHMT1; the disease is polycystic ovary syndrome.