Congruent with aprevious study, an altered expression pattern, particularly the upregulationof il6 and activation of tnf-α,a master regulator, was found in the ovary of BPA lineage, indicatingvisceral fat mediation due to the activation of proinflammatory cytokines(TNF-α, IL-6) and tissue macrophages,critical drivers of PCOS-obesity multifactorial disease.101,102 The downregulation of igf1 in the ovary of theBPA lineage could also have contributed to impaired follicular growth,as reflected histologically. This evidence concerns the gene IGF1 and obesity disorder.