Intrathecal administration of human umbilical cord-derived mesenchymal stem cells (HUC-MSCs) or oral administration of Crotalphine (CRO) alleviated neuropathic pain or pain induced by experimental autoimmune encephalomyelitis through inhibiting glial cells activation and IL-17 release [22, 23]. Here, IL17A is linked to experimental autoimmune encephalomyelitis.