To evaluate the clinical relevance of the findings in mice, we first checked the expression level of Adgrf1 in human liver from a publicized transcriptome dataset Gene Expression Omnibus (GEO; Profile # GDS4881) with human liver biopsy of different phases from control to NAFLD was checked (Ahrens et al., 2013). Here, ADGRF1 is linked to metabolic dysfunction-associated steatotic liver disease.