Overexpressing Adgrf1 in the liver of STC-fed mice did not affect body weight (Figure 2—figure supplement 1D), fasting glucose level (Figure 2—figure supplement 1E), fasting insulin level (Figure 2—figure supplement 1F), and homeostatic model assessment for insulin resistance (HOMA-IR; Figure 2—figure supplement 1G). Here, ADGRF1 is linked to Insulin resistance.