They were more predominant in controls than in cases, suggesting that they might be protective for AMD, as shown by Fritsche and the EYE-RISK Consortium: CFH rs10922109 OR = 0.37, P = 3.93− 47 (EYE-RISK Consortium) and OR = 0.38 P = 9.6− 618 (IAMDGC) and C2/CFB/SKIV2L rs429608 OR = 0.62, P = 1.00− 6 (EYE-RISK Consortium) and OR = 0.57 P = 1.2− 103 (IAMDGC) [19, 30]. This evidence concerns the gene CFH and age-related macular degeneration.