TGFB1 and immune system disorder: Similar to the therapeutic effect of T.s treatment, after vx-765 intervention, pro-inflammatory cytokine IL-6 in DSS-induced colitis mice was significantly reduced, while anti-inflammatory cytokines such as IL-4, IL-10 and TGF-β were significantly increased (Fig. 6d), indicating blockade of caspase-1-mediated pyroptosis could balance the immune disorder of DSS-induced colitis in mice.