The m6A-dependent modification is reversible and regulated by methyltransferases (METTL3, METTL14, and WTAP), demethylases (FTO and ALKBH5), and m6A-binding proteins (such as YTH domain family proteins and IGF2BP family proteins), which are essential for cancer initiation and progression [6]. Here, ALKBH5 is linked to cancer.