Additionally, genetically predicted inhibition of HMGCR had a positive correlation effect on the risk of RA (IVW: OR [95%] = 1.58 [1.19 to 2.11], p = 1.67 × 10−3), while inhibition of PCSK9 had no effect on the risk of RA (IVW: p = 0.17). The gene discussed is PCSK9; the disease is rheumatoid arthritis.