Encouragingly, our updated analysis still demonstrated that the inhibition of PCSK9 was associated with a significantly increased risk of asthma (IVW: OR [95%] = 1.15 [1.03 to 1.29], p = 1.68 × 10−2) (Additional file 1: Table S3 and Fig. 2), and this result exhibited no significant heterogeneity or horizontal pleiotropy (Additional file 1: Table S5). Here, PCSK9 is linked to asthma.