Genetically predicted inhibition of PCSK9 had an obvious protective effect on SLE in both the IVW method (OR [95%] = 0.47 [0.30 to 0.76], p = 1.74 × 10−3) and weighted median method (OR [95%] = 0.38 [0.21 to 0.68], p = 1.21 × 10−3), while inhibition of HMGCR did not reach statistical significance (IVW: p = 0.46; weighted median: p = 0.39) (Fig. 2). The gene discussed is HMGCR; the disease is systemic lupus erythematosus.