Besides, both inhibition of PCSK9 and HMGCR could significantly increase the risk of asthma (PCSK9: IVW: OR [95%] = 1.19 [1.07 to 1.33], p = 1.97 × 10−3; HMGCR: IVW: OR [95%] = 1.21 [1.04 to 1.40], p = 1.17 × 10−2) and CD (PCSK9: IVW: OR [95%] = 1.38 [1.05 to 1.83], p = 2.28 × 10−2; HMGCR: IVW: OR [95%] = 1.60 [1.08 to 2.39], p = 2.04 × 10−2)(Fig. 2). The gene discussed is PCSK9; the disease is asthma.