The aims of our study were to: (i) characterise Aβ and tau pathology in the temporal and cerebellar cortex; (ii) explore the expression of TSPO and other microglial markers through the course of the disease; (iii) compare TSPO expression and AD pathology between both regions, particularly in view of the use of the cerebellum as a reference region for in vivo TSPO PET scans; (iv) assess the inflammatory microenvironment of both regions; and (v) determine if the rs6971 polymorphism affects TSPO immunoexpression. The gene discussed is MAPT; the disease is Alzheimer disease.