While the current study did not demonstrate reduced eosinophilic lung inflammation in Par2 KO mice, we observed increased phosphorylation of NF-κB protein in whole lung lysates from Par2 KO mice exposed to HDM extract or co-exposed to HDM extract and MWCNTs, indicating that PAR2 regulates some aspects of inflammation. The gene discussed is NFKB1; the disease is inflammation.